Septerna, Inc.

government agency securities, commercial paper, and corporate debt securities, are classified as Level 2.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

government agency securities 4,224 4,224 Total measured at fair value $ 544,025 $ 63,736 $ 480,289 $ Marketable Securities As of June 30, 2026 and December 31, 2025, the Company s marketable securities consist of debt securities, including U.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

The collaboration included the Company's most advanced preclinical metabolic program focused on developing an oral small molecule agonist to the GIP receptor.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

Fair value is determined based on a three-tier hierarchy under the authoritative guidance for fair value measurements and disclosures that prioritizes the inputs used in measuring fair value as follows: Level 1: Unadjusted quoted prices in active markets that are accessible at the measurement date for identical, unrestricted assets or liabilities; Level 2: Quoted prices in markets that are not active or inputs which are observable, either directly or indirectly, for substantially the full term of the asset or liability; and Level 3: Prices or valuation techniques that require inputs that are both significant to the fair value measurements and unobservable (i.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Septerna’s Annual Report on Form 10-K for the year ended December 31, 2025, as well as any subsequent filings with the Securities and Exchange Commission.

SEC original ↗Septerna, Inc. — Earnings release (8-K exhibit)EX-99May 11, 2026

Legal Proceedings 34 Item 1A.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

Although we believe that the expectations reflected in these forward-looking statements are reasonable, these statements relate to future events or our future operational or financial performance, and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

federal government shutdown or reduced resources, new or increased international tariffs and retaliatory tariffs, trade protection measures, economic sanctions and economic slowdowns or recessions that may result from such developments which could harm our research and development efforts as well as the value of our common stock and our ability to access capital markets; and other risks and uncertainties, including those listed under the section titled Risk Factors in Part II, Item 1A in this Quarterly Report.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

You should not place undue reliance on forward-looking statements because they involve known and unknown risks, uncertainties, and other factors, which are, in some cases, beyond our control and which could materially affect results.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026

If one or more of these risks or uncertainties occur, or if our underlying assumptions prove to be incorrect, actual events or results may vary significantly from those implied or projected by the forward-looking statements.

SEC original ↗Septerna, Inc. — 10-Q Quarterly report10-QAug 10, 2026